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KMID : 0358519940060020348
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Korean Journal of Occupational and Environmental Medicine
1994 Volume.6 No. 2 p.348 ~ p.363
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Study on the Progression of Biological Effects of Workers Following Termination of CS2 Exposure
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염용태
김광종/김순덕/이은일/박혜경/정해륜/권희규
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Abstract
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The object of this study was to evaluate the possibility of new development of polyneuropathy and microaneurysm in fundus in workers who did not have polyneuropathy and microaneurysm in fundus in the electromyogram(EMG) and ophthalmoscopic
examination.
The total number of subjects was 144 workers who had the EMG and funduscopic examination done at least twice. There were two kinds of subjects. The one of subjects was a total of 120 workers who were examined at least twice in their annual health
examination for carbon disulfide poisoning. The other subjects were a total of 24 volunteer who worked in the rayon manufacturing factory.
@ES The results were as follows:
@EN 1. There was no cases of polyneuropathy or microaneurysm in volunteers.
2. The new cases of polyneuropathy were detected in 12 (14.3%) out of 84 subjects, and those of microaneurysm in fundus were detected in 30 (26.5%) out of 113 subjects.
3. We investigated the variables showing difference between the new cases and other cases who had no polyneuropathy or microaneurysm in fundus in repeated examinations. The both of polyneuropathy and microaneurysm cases had higher cummulative
exposure
index, and most of them were workers in the department of spinning where the concentration of CS2 in air was highest in the rayon manufacturing company.
4. There were no statistically significant variables by logistic regression analysis in the polyneuropathy cases. The cummulative index and the department were the statistically significant variable in the development of microaneurysms.
5. Above findings showed that workers who had high exposure history of CS2 as the workers in spinning department, had greater chance to develop the polyneuropathy or microaneurysm. But there were some limitations to conclude the association
between the
CS2 exposure and development of polyneuropathy or microaneurysm. Limitations are follows: short follow-up period, small number of cases, and possibility of measurement error including imperfect sensitivity or specificity of electrodiagnostic test
and
examiner's difference of ophthalmoscopic examination. Therefore more cases and longer follow-up period are needed to study the progression of polyneuropathy or microaneurysm.
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